Rosiglitazone

Brand Name	Manufacturer Name	Distributor	Drug Strength	Packaging	Formulation	Formulation Strength	Price
Avandia	GlaxoSmithkline	GlaxoSmithKline	4mg	28	Tablet	per tablet	KES 763.90

Rosiglitazone More info
Mode Of Action	Thiazolidinedione are effective only in presence of insulin. They binds selectively at peroxisome proliferator, an activated receptor?gamma found in the adipose tissue; skeletal muscle, and liver. Activation of these receptors modulates transcription of several insulin responsive genes that control glucose and lipid metabolism.
Drug Indication	Diabetic type 2. It is used as monotherapy or in combination with metformin.
Precautions	Breastfeeding; it may cause resumption of ovulation in pre-menopausal anovulatory patients.
Contra-Indications	Breastfeeding; type 1 diabetes; diabetes keto-acidosis; hepatic disorders.
Side Effects	Peripheral oedema; URTI; back pain; headache; anaemia.
Dosage	As monotherapy: Initially 4mg/day orally administered OD or BD without regard to meals. If the response is inadequate after 12 wks, the dose may be increased to 8mg/day administered OD or BD. Combination with metformin: Initially 4mg/day orally administered OD or BD. If the response is inadequate after 12 weeks, the dose may be increased to 8 mg/day OD or BD.
Drug Category	DRUGS AFFECTING NUTRITION AND METABOLISM
Drug Sub-Category	Thiazolidinediones

1. Rosiglitazone / Metformin
Mode Of Action	Thiazolidinedione are effective only in presence of insulin. They binds selectively at peroxisome proliferator, an activated receptor?gamma found in the adipose tissue; skeletal muscle, and liver. Activation of these receptors modulates transcription of several insulin responsive genes that control glucose and lipid metabolism.
Drug Indication	Uncomplicated and non-ketonic diabetes mellitus (maturity onset type II diabetes).
Precautions	See under Rosiglitazone and metformin respectively
Contra-Indications	See under Rosiglitazone and metformin respectively
Side Effects	See under Rosiglitazone and metformin respectively
Pregnancy Category	Category C
Pregnancy Category Description	Drugs which, owing to their pharmacological effects, or may be suspected of causing detrimental effects on human foetus or neonates without causing malfunctions. These effects may be reversible
Drug Category	DRUGS AFFECTING NUTRITION AND METABOLISM
Drug Sub-Category	Sulphonylureas

Brand Name	Manufacturer Name	Distributor	Drug Strength	Packaging	Formulation	Formulation Strength	Price
Avandamet	GlaxoSmithkline	GlaxoSmithKline	2mg/500mg	28	Tablet	per tablet	KES 317.30